منابع مشابه
Sodium Channel and Sodium
Levels of sodium pump and of sodium channels were measured at different stages of membrane purification. Microsomal fractions of normal human muscle have maximal binding capacities for tetrodotoxin of 230 fmol/mg of protein and of 7.4 pmol/mg of protein for ouabain. Dissociation constant for the complexes formed by the tetrodotoxin derivative and by ouabain with their respective receptors were ...
متن کاملMountain excitement
theory? What is its legacy today in biology? Quite a few mathematical fads have burst onto the popular press, promising great new insights into biology: information theory, catastrophe theory, chaos theory, and most recently complexity theory, to name just a few. All were quite useful in their founding fields (except complexity, which has proven slippery to even define), but all failed to live ...
متن کاملFrom GWAS to function: genetic variation in sodium channel gene enhancer influences electrical patterning.
The electrical activity of the heart depends on the correct interplay between key transcription factors and cis-regulatory elements, which together regulate the proper heterogeneous expression of genes encoding for ion channels and other proteins. Genome-wide association studies of ECG parameters implicated genetic variants in the genes for these factors and ion channels modulating conduction a...
متن کاملSpliced Sodium Channel Transcripts
Sodium (Na) channel cDNAs were synthesized from RNA isolated from rat brain, cardiac muscle, and skeletal muscle. Partial cDNAs coding for the largest cytoplasmic loop of the Na channel were amplified with PCR. Sequence analysis of these cDNAs revealed that Na channel cDNAs originally described as brain genes were also expressed in both cardiac and skeletal muscle. Some of these cDNAs were isof...
متن کاملTemperature-dependent model of human cardiac sodium channel
Cardiac sodium channels are integral membrane proteins whose structure is not known at atomic level yet and their molecular kinetics is still being studied through mathematical modeling. This study has focused on adapting an existing model of cardiac Na channel to analyze molecular kinetics of channels at 9-37°C. Irvine et al developed a Markov model for Na channel using Neuronal Network Model ...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 2018
ISSN: 0022-1295,1540-7748
DOI: 10.1085/jgp.201812151